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November 14, 2012

Treatment With Silymarin for Hepatitis C Virus

Author Affiliations

Author Affiliation: Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria (peter.ferenci@meduniwien.ac.at).

JAMA. 2012;308(18):1856-1857. doi:10.1001/jama.2012.13741

To the Editor: Dr Fried and colleagues1 reported the effects of oral silymarin in patients with chronic hepatitis C virus (HCV) infection who had not responded to standard antiviral treatment. Oral silymarin is used worldwide as a treatment for liver disorders, either by prescription or as a nutritional supplement. A controlled study showed a survival benefit in patients with cirrhosis,2 and other data indicated that the intravenous preparation is a potent antiviral agent against HCV.3