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November 21, 2012

Cardiovascular Disease Risk Prediction Factors—Reply

Emanuele Di Angelantonio, MD, PhD; Pei Gao, PhD; John Danesh, FRCP; et al for the Emerging Risk Factors Collaboration
Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Department of Public Health and Primary Care, University of Cambridge, Cambridge, England (erfc@medschl.cam.ac.uk).

JAMA. 2012;308(19):1969. doi:10.1001/jama.2012.14045

In Reply: The ERFC reported a meta-analysis of individual participant data involving 165 544 people in 37 prospective studies, showing that the addition of information on various lipid-related markers can slightly improve the prediction of first cardiovascular disease outcomes. We can confirm that these findings are accurate and valid. The relevant source material has been provided in the article (including its 38-page supplement) and cited design and methods reports.1,2