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Medical News & Perspectives
December 26, 2012

New Research on Alzheimer Treatments Ventures Beyond Plaques and Tangles

JAMA. 2012;308(24):2553-2555. doi:10.1001/jama.2012.93816

New Orleans—Despite decades of research on treatments for Alzheimer disease (AD), no therapies have been found to prevent, halt, or reverse this neurodegenerative disorder, which affects about 5.4 million people in the United States alone.

That's not for lack of trying, said Lennart Mucke, MD, PhD, director of the Gladstone Institute of Neurological Disease at the University of California, San Francisco, who spoke at the annual meeting of the Society for Neuroscience. While research is contributing to a better understanding of the disease, these mechanistic insights haven't yet translated into successful therapies, he said.