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Lab Reports
January 2, 2013

Lithium for Down Syndrome

JAMA. 2013;309(1):20. doi:10.1001/jama.2012.173444

Lithium improves the performance of mice with Down syndrome in tasks related to contextual learning, spatial memory, and object discrimination, report researchers at the Istituto Italiano di Tecnologia, in Genoa, Italy (Contestabile A et al. J Clin Invest. doi:10.1172/JCI64650 [published online December 3, 2013]. The improvement occurred because the drug, which is commonly used for the treatment of mood disorders, restored neurogenesis in the hippocampus of treated mice.