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Lab Reports
January 2, 2013

New Clues to Sleeping Sickness

JAMA. 2013;309(1):20-20. doi:10.1001/jama.2012.131057

New research has revealed the structure of a key enzyme from the parasite that causes African trypanosomiasis, or sleeping sickness (Redecke L et al. Science. doi:10.1126/science.1229663 [published online November 29, 2012]). The enzyme, called Trypanosoma brucei cysteine protease cathepsin B (TbCatB), helps degrade host proteins.