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January 2, 2013

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Events

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliation: Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada (evan.lewis@utoronto.ca).

JAMA. 2013;309(1):27. doi:10.1001/jama.2012.116654

To the Editor: Dr Rizos and colleagues1 conducted a systematic review and meta-analysis of omega-3 polyunsaturated fatty acid (PUFA) supplementation and cardiovascular disease events. While the overall conclusion of the article was omega-3 PUFA intake was not associated with lower cardiovascular risk, the dietary or supplemental intake and source of omega-3 PUFAs are 2 factors that may not have been adequately addressed.