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January 2, 2013

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Events

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: First Department of Cardiology, Athens Medical School, Athens, Greece (Drs Vlachopoulos and Stefanadis) (cvlachop@otenet.gr); and Cardiac Department, Euroclinic Athens, Athens, Greece (Dr Richter).

JAMA. 2013;309(1):27. doi:10.1001/jama.2012.116651

To the Editor: Omega-3 PUFA supplementation was not associated with a lower risk of any cardiovascular outcome in a study by Dr Rizos and colleagues.1 These results should be interpreted with caution due to the methodological shortcomings of the study and issues of interpretation.

First, the correction for multiple comparisons applied by the authors is not suggested by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and has rarely been used in other meta-analyses. Thus, the authors introduced an unnecessarily stringent level of significance (P < .0063 instead of P < .05), hampering interpretation of the results.