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January 2, 2013

Statistical Analysis Plans in Observational Research

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Center for Outcomes Research and Analytics, Henry Ford Health System, Detroit, Michigan (Dr Trinh; trinh.qd@gmail.com); and Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada (Ms Sun).

JAMA. 2013;309(1):32. doi:10.1001/jama.2012.56907

To the Editor: The need for more rigorous and stringent hypothesis testing in clinical research, particularly in the context of retrospective observational studies, was highlighted by Drs Thomas and Peterson.1 The increasing availability of health data from federal sources such as the Agency for Healthcare Research and Quality and the Centers for Medicare & Medicaid Services makes the topic timely and relevant.

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