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January 9, 2013

Bisphenol A and Obesity in Children and Adolescents—Reply

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Department of Pediatrics, New York University School of Medicine, New York (Drs Trasande and Attina) (leonardo.trasande@nyumc.org); and New York University Wagner School of Public Service, New York (Dr Blustein).

JAMA. 2013;309(2):134-135. doi:10.1001/jama.2012.91939

In Reply: In our analysis of data from the 2003-2008 National Health and Nutrition Examination Survey (NHANES), we found associations of urinary BPA (but not other chemically similar environmental phenols) with body mass index z score and obesity in children and adolescents, whether the urinary concentration was categorized in quartiles or analyzed as a continuous variable. Dr Brent asserts that we failed to account for the lipophilic nature of BPA and therefore its propensity to be stored in the adipose tissue of obese individuals (especially compared with other environmental phenols), invalidating our use of their urinary concentrations as tests of specificity.