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January 16, 2013

Noninvasive Approach to Assess Coronary Artery Stenoses and Ischemia

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Department of Radiology, Charité–Universitätsmedizin Berlin, Berlin, Germany (Dr Dewey; dewey@charite.de); Andreas Grüntzig Cardiac Catheterization Laboratories and Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland (Dr Gaemperli); and Department of Medical Statistics, Informatics, and Documentation, University Hospital of Friedrich-Schiller University Jena, Jena, Germany (Dr Schlattmann).

JAMA. 2013;309(3):233-236. doi:10.1001/jama.2012.157199

To the Editor: The Determination of Fractional Flow Reserve by Anatomic Computed Tomographic Angiography (DeFACTO) study1 assessed a noninvasive approach to ascertain the functional significance of coronary artery stenoses. The results, using fractional flow reserve (FFR) derived from coronary computed tomographic (CT) angiography (FFRCT), are promising even though the primary prospectively defined end point was not met. This technique may guide coronary revascularization but one should also note the limited agreement of FFRCT with invasive FFR in ischemic lesions.2