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Lab Reports
February 6, 2013

High-Cholesterol Pigs

JAMA. 2013;309(5):431-431. doi:10.1001/jama.2013.54

A team led by scientists in Denmark has genetically engineered a pig model for atherosclerosis that develops severe hypercholesterolemia and human-like progressive atherosclerotic lesions (Al-Mashhadi RH et al. Sci Transl Med. 2013;5[166]:166ra1). The accomplishment is significant because normal pigs have a low propensity to develop atherosclerosis even with prolonged high-fat, high-cholesterol diets.