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February 27, 2013

Antiviral Therapy and Hepatitis B Virus–Related Hepatocellular Carcinoma Recurrence

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan (Ms Yeh and Dr Lai) (mslai@cph.ntu.edu.tw); and Hepatitis Research Center, National Taiwan University and Hospital, Taipei, Taiwan (Dr Chen).

JAMA. 2013;309(8):765-767. doi:10.1001/jama.2013.571

To the Editor: Nucleoside analogues are an effective treatment against HBV infection. However, previous studies have yielded inconclusive results regarding a reduction in the risk of HCC recurrence following the use of these treatments due to the small number of patients. Using a nationwide cohort, Dr Wu and colleagues1 reported survival benefits for patients treated with nucleoside analogues. We have 2 comments to make regarding their findings.