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February 27, 2013

Antiviral Therapy and Hepatitis B Virus–Related Hepatocellular Carcinoma Recurrence—Reply

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan (Dr Wu; chun@vghtc.gov.tw); and Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan (Dr Hsu).

JAMA. 2013;309(8):765-767. doi:10.1001/jama.2013.574

In Reply: Dr Hsu and Ms Yeh and colleagues raise concerns about the designation of our study population, given that the Taiwan National Health Insurance Research Database lacked direct information for determining curativeness of resection, pathological details, and cancer stage. These limitations were addressed in our study by restricting enrollment to patients who received liver resection as the only treatment for HCC. Had the resection been incomplete, patients would most likely have had additional surgery or other treatment and been excluded.1