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March 13, 2013

Multivitamins for Cancer Prevention in Men

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: National Institute of Statistical Sciences, Research Triangle Park, North Carolina (Dr Young; young@niss.org); Laurel, Maryland (Dr Katzoff).

JAMA. 2013;309(10):980-981. doi:10.1001/jama.2013.1181

To the Editor: Dr Gaziano and colleagues1 reported on the multivitamin segment of a large randomized clinical trial looking at all combinations of 4 dietary supplements: multivitamins, vitamin E, vitamin C, and beta carotene. The 2×2×2×2 factorial trial was designed to evaluate a number of outcomes, including cardiovascular events, eye disease, and cognitive decline, but this article reported on total and other common site cancers, including total and cancer mortality, 21 end points in all (Table 2 in article).