Letters Section Editor: Jody W. Zylke, MD, Senior Editor.
Author Affiliations: Department of Medicine (Dr Mehta; Geeta.email@example.com) and Department of Pharmacy and Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada (Dr Burry); Departments of Medicine, Clinical Epidemiology & Biostatistics, St Joseph's Healthcare, Hamilton, Ontario, Canada (Dr Cook).
In Reply: Drs Brun-Bruisson and Schortgen question the generalizability of our results to units with different staffing models. The nurse-to-patient ratio in enrolling centers ranged from 1:1 to 1:2 and was not altered for the trial. Sedation monitoring occurred hourly for the first 7 days and every 2 hours thereafter. Administration of the Sedation-Agitation scale or the Richmond Agitation Sedation scale takes less than 1 minute to perform and can be performed concurrently with other nursing care. Regarding workload, the mean visual analog scale administered by the nurses was similar on study days 1 through 2 compared with days 3 through 7 in both the daily sedation interruption (4.35 vs 4.34) and sedation protocol group (3.96 vs 3.97).
Mehta S, Burry L, Cook D, SLEAP Investigators FT. Sedation Interruption for Mechanically Ventilated Patients—Reply. JAMA. 2013;309(10):982–983. doi:10.1001/jama.2013.1007
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