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March 27, 2013

Aspirin Use and Risk of Macular Degeneration

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliation: Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran (norozzadeh@gmail.com).

JAMA. 2013;309(12):1226. doi:10.1001/jama.2013.2038

To the Editor: Dr Klein and colleagues1 demonstrated that regular aspirin use 10 years prior was associated with a small but statistically significant increase in the risk of incident late and neovascular age-related macular degeneration (AMD). I have a few comments regarding the potential limitations of the study.

First, the definition used to describe regular aspirin users (at least twice per week for >3 months, with a cumulative dose of only 24 pills) may not have properly defined regular use. Aspirin is an over-the-counter drug and even a healthy person may take more than 24 pills over the 5 or 10 years of the study period.