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March 27, 2013

Aspirin Use and Risk of Macular Degeneration

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China (tangsb@sysu.edu.cn).

JAMA. 2013;309(12):1227-1228. doi:10.1001/jama.2013.2035

To the Editor: The article by Dr Klein and colleagues1 found an association between incidence of late and neovascular AMD and regular aspirin use 10 years prior. We think there are some factors that they did not include in the study.

People who regularly use aspirin are usually patients with cardiovascular disease or arthritis, or those at high risk of these diseases. Blood pressure, glycated hemoglobin, inflammatory factors such as leukocyte count and C-reactive protein level, body mass index, history of cardiovascular disease and arthritis, and smoking and drinking status of participants were adjusted for in the statistical models. However, some important risk factors for cardiovascular disease were not included, such as hyperlipidemia history or cholesterol, triglyceride, and lipoprotein cholesterol levels.