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April 10, 2013

Sustained Virological Response to Treatment in Patients With Chronic Hepatitis C—Reply

Author Affiliations

Author Affiliations: Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands (h.janssen@erasmusmc.nl).

JAMA. 2013;309(14):1457. doi:10.1001/jama.2013.2733

In Reply: Mr Maisonneuve and Dr Bruno raise the possibility that the association between SVR and reduced occurrence of hepatocellular carcinoma among patients with chronic HCV infection and advanced hepatic fibrosis in our analyses could be confounded by HCV genotype or subtype. Therefore, as suggested, we have performed a multivariable Cox regression analysis adjusting for each specific HCV genotype. With this alternative model, the association between SVR and time to hepatocellular carcinoma remained similar (hazard ratio [HR], 0.16 [95% CI, 0.07-0.37]; P < .001) compared with the original model that adjusted for HCV genotype 3 vs nongenotype 3 (HR, 0.19 [95% CI, 0.08-0.44]; P < .001).