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April 17, 2013

Infantile Colic and Migraine

Author Affiliations

Author Affiliations: Departments of Pediatrics (Dr Epstein) and Neurology (Drs Epstein and Zee), Feinberg School of Medicine, Northwestern University, and the Ann & Robert H. Lurie Children's Hospital of Chicago (Dr Epstein), Chicago, Illinois.

JAMA. 2013;309(15):1636-1637. doi:10.1001/jama.2013.3873

Clinicians have long suspected an association between migraine and infantile colic.1-3 Previous studies have linked maternal migraine with infantile colic.4 In this issue of JAMA, a case-control study of 208 children with migraine and 471 age-matched controls by Romanello and colleagues5 answers a long-standing scientific question by demonstrating an association between migraine, with or without aura, and infantile colic in pediatric patients, with an odds ratio of 6.61 (95% CI, 4.38-10.00). The specificity of this finding is bolstered by the absence of any association between tension headaches and infantile colic in a separate group of 120 children.5

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