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April 24, 2013

Overweight, Obesity, and All-Cause Mortality

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Department of Physiology, University of Valencia, Valencia, Spain (jose.vina@uv.es).

JAMA. 2013;309(16):1679. doi:10.1001/jama.2013.3080

To the Editor: Dr Flegal and colleagues1 concluded that grade 1 obesity was not associated with higher all-cause mortality and that overweight was associated with significantly lower all-cause mortality. Other studies have shown that obesity in different populations, such as elderly people and patients with cardiovascular diseases, is also paradoxically not associated with a higher but rather with a lower mortality risk.2 This has been termed the obesity paradox. The study by Flegal et al extends these findings to the general population.