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May 8, 2013

Helicobacter pylori Susceptibility in the GWAS Era

Author Affiliations

Author Affiliation: Division of Applied Medicine, Institute of Medical Sciences, School of Medicine and Dentistry, Aberdeen University, Foresterhill, Aberdeen, United Kingdom.

JAMA. 2013;309(18):1939-1940. doi:10.1001/jama.2013.5590

Helicobacter pylori infection remains one of the most common chronic bacterial infections worldwide and is causally linked to the pathogenesis of peptic ulcer disease, gastric adenocarcinoma, and MALT (mucosa-associated lymphoid tissue) lymphoma.1 However, the majority of infected patients generally remain asymptomatic and never develop significant disease. Because of its wide prevalence and causal association with serious disease outcomes, this infection has deservedly commanded the attention and dedication of researchers across the globe.