Pelvic floor disorders, including pelvic organ prolapse, urinary incontinence, fecal incontinence, and other sensory disorders of the gastrointestinal and genitourinary tract, are common with nearly 1 in 4 US women having at least 1 pelvic floor condition.1 In this issue of JAMA, Nygaard and colleagues2 present findings from the extended Colpopexy and Urinary Reduction Efforts (extended CARE) trial. The original CARE trial3 was a double-blind randomized trial of 322 women mostly with advanced (stage 3-4) prolapse and without stress incontinence symptoms undergoing an open abdominal synthetic mesh sacrocolpopexy procedure either with or without a urethropexy for prevention of stress urinary incontinence.