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Lab Reports
June 5, 2013

Stem Cells to Treat Epilepsy

JAMA. 2013;309(21):2205. doi:10.1001/jama.2013.6698

Progenitors of inhibitory neurons that are injected into the hippocampal region of adult epileptic mice could reduce the frequency of seizures and correct the animals' behavioral deficits, such as hyperactivity and aggression, report researchers from the University of California, San Francisco (Hunt RF et al. Nat Neurosci. doi:10.1038/nn.3392 [published online May 5, 2013]).

The investigators demonstrated that the injected progenitor cells differentiated into functional inhibitory interneurons and expressed genes and proteins characteristic of the cells.