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June 5, 2013

Maternal Folic Acid Supplementation and Risk of Autism

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia (Dr Vahabzadeh); and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (Dr McDougle; cmcdougle@partners.org).

JAMA. 2013;309(21):2208. doi:10.1001/jama.2013.4876

To the Editor: Dr Surén and colleagues1 reported on the decreased incidence of autistic disorder in children whose mothers received prenatal folic acid supplementation around the time of conception. The study expands on their previous report of an association between prenatal folic acid and severe childhood language delay,2 a key feature of autism spectrum disorders.