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November 2, 2011

Adherence to a Healthy Lifestyle and Sudden Cardiac Death Among Women—Reply

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts (schiuve@hsph.harvard.edu).

JAMA. 2011;306(17):1861. doi:10.1001/jama.2011.1579

In Reply: Dr Gross and colleagues raise an important concern regarding the possibility that depression may impair an individual's ability to adhere to a healthy lifestyle. Depressive symptoms have been associated with risk of SCD within this cohort previously1; thus, the association between lifestyle and SCD may be confounded in part by depressive symptoms. Information on depression and depressive symptoms was not available at the beginning of study follow-up in 1984 and not included in our multivariable models.