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May 5, 1999

Prostatectomy, External Beam Radiation Therapy, or Brachytherapy for Localized Prostate Cancer—Reply

JAMA. 1999;281(17):1583-1586. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-17-jbk0505

In Reply: While Dr Fuller, Dr Vicini and colleagues, Drs Potters and Freeman, and Dr Sharkey present thoughtful comments, a few points of clarification are needed. First, in the "Comment" section of our article, we clearly state that PSA outcome after the current "standard of practice" of external beam radiation plus implantation with or without neoadjuvant androgen deprivation therapy should be prospectively compared with radical prostatectomy or external beam radiation therapy controlling for the PSA, biopsy Gleason score, and clinical T-stage. Only with such comparisons can the "standard of practice" become clinically valid.