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May 5, 1999

Thyroid Cancer in Patients With Hepatitis C Infection

JAMA. 1999;281(17):1588. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-17-jbk0505

To the Editor: Hepatitis C virus (HCV) is the most frequent etiologic factor for non-A and non-B chronic hepatitis worldwide; moreover, a constellation of extrahepatic manifestations has been described in individuals infected with HCV.1 Because of its lymphotropism,2 HCV can represent a chronic stimulus for the immune system leading to a variety of autoimmune and lymphoproliferative disorders such as mixed cryoglobulinemia, membranoproliferative glomerulonephritis, B-cell lymphomas, and autoimmune thyroiditis.1,3-5 Thyroiditis is frequently found in patients with type C chronic hepatitis during interferon therapy.5 Moreover, thyroiditis can be regarded as preneoplastic condition.6 We report the prevalence of thyroid cancer in a series of patients with chronic hepatitis C infection.

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