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Medical News and Perspectives
August 24/31, 2005

Could a Novel Vaccine Help Smokers Quit?

JAMA. 2005;294(8):891-892. doi:10.1001/jama.294.8.891

To cease smoking is the easiest thing I ever did. I ought to know because I’ve done it a thousand times.” This popular quote, attributed to Mark Twain, mockingly captures the difficulties of long-term abstinence for nicotine-dependent individuals.

Clinicians have many more tools to treat nicotine dependence than were available in Twain’s time. But even though such approaches as nicotine replacement, bupropion, and behavioral therapies have helped many individuals quit, relapse is common.