To cease smoking is the easiest thing I ever did. I ought to know because
I’ve done it a thousand times.” This popular quote, attributed
to Mark Twain, mockingly captures the difficulties of long-term abstinence
for nicotine-dependent individuals.
Clinicians have many more tools to treat nicotine dependence than were
available in Twain’s time. But even though such approaches as nicotine
replacement, bupropion, and behavioral therapies have helped many individuals
quit, relapse is common.
Kuehn BM. Could a Novel Vaccine Help Smokers Quit?. JAMA. 2005;294(8):891–892. doi:10.1001/jama.294.8.891
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