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Comment and Response
July 24/31, 2013

Chelation Therapy and Cardiovascular Outcomes

Author Affiliations
  • 1Munroe Regional Medical Center, Ocala, Florida
JAMA. 2013;310(4):430-431. doi:10.1001/jama.2013.7933

To the Editor The surprising finding that chelation therapy modestly reduces cardiovascular outcomes1 raises 2 important issues: What is the mechanism of benefit and how valid are the results?

For further scientific study, the investigators may wish to consider 2 reports2,3 that identified a relationship between cadmium exposure and cardiovascular risk. The findings from the reports may be important because cadmium, a constituent of cigarette smoke, is avidly bound by EDTA.4

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