To the Editor The surprising finding that chelation therapy modestly reduces
cardiovascular outcomes1 raises 2 important issues: What is
the mechanism of benefit and how valid are the results?
For further scientific study, the investigators may wish to consider 2 reports2,3 that identified a relationship between cadmium
exposure and cardiovascular risk. The findings from the reports may be important because cadmium, a
constituent of cigarette smoke, is avidly bound by EDTA.4
Bittl JA. Chelation Therapy and Cardiovascular Outcomes. JAMA. 2013;310(4):430–431. doi:10.1001/jama.2013.7933