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Comment & Response
July 24/31, 2013

Chelation Therapy and Cardiovascular Outcomes—In Reply

Author Affiliations
  • 1Division of Cardiology, Columbia University at Mount Sinai Medical Center, Miami Beach, Florida
  • 2Duke Clinical Research Institute, Durham, North Carolina
JAMA. 2013;310(4):431-432. doi:10.1001/jama.2013.7954

In Reply Dr Bittl references evidence that associates cadmium levels with atherosclerosis and points out that EDTA is an effective chelator for many xenobiotic heavy metals. Heavy metals promote oxidant stress and, as such, may be causative in atherosclerosis.1 The heavy metal hypothesis, as mentioned in the Discussion section of our article, is a possible explanation for the results of TACT.