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June 4, 1898


JAMA. 1898;XXX(23):1361-1362. doi:10.1001/jama.1898.02440750049009

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A recent article concerning researches in the etiology of articular rheumatism, recalls those lately carried on by Vienna investigators. Their work was directed not only toward discovery of the causative factor of rheumatism, but to determine why the joint forms a locus minoris resistentiæ.

The histologic studies of Hofbauer led him to the conclusion that the low resisting power was due to the structure of the synovial membrane. Not only is it very vascular in all its layers, but its vessels passing close to the joint surface, from which they are separated by a thin layer of tissue, bend on themselves and pursue a tortuous course directly under, and parallel to, the surface of the joint. Some authors assert that the capillaries extend free into the joint cavity, covered only by synovial cells. He failed to confirm the findings of Buday, viz., that the endothelial cells lining the capillaries protrude