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Original Contributions
December 14, 1964

Effect of Corticotropin Upon Triglyceride LevelsResults in Coronary-Prone Subjects and Patients With Addison's Disease

JAMA. 1964;190(11):959-964. doi:10.1001/jama.1964.03070240005001

Elevation in the preprandial and postprandial serum triglyceride levels and increased turbidity of the postprandial sera observed in subjects exhibiting a behavior pattern (type A) associated with a high incidence of clinical coronary artery disease could be abolished by the prior administration of corticotropin (ACTH) but not by hydrocortisone. Patients with Addison's disease (adrenal cortical hypofunction) receiving adequate corticosteroid therapy were observed to exhibit postprandial serum triglyceride levels almost identical with those observed in type A subjects. Such levels, however, could not be altered by corticotropin administration.