There is much discussion as to whether Hodgkin's disease is unicentric or multicentric in origin. It is the concept of the pathogenesis of the disease that determines the attitude of the physician toward the patient and in turn the vigor and aggressiveness of therapy. If the opinion held is that the disease is multifocal and therefore a systemic process, the therapeutic approach is conservative and minimal therapy is used to control symptoms as they arise. That is, survival cannot be effected by present therapeutic modalities, and one should not overtreat the patient with radical approaches that may add to discomfort and lead to complications and even to the earlier death of the individual. The opposite view is that the disease originates in one site or lymphatic-bearing area. Thomson,' in particular, has developed the view that the thymus gland is the probable primary site of Hodgkin's disease, and that the failure
Rubin P. Hodgkin's Disease: Curability of Localized Hodgkin's Disease by Surgery, Radiotherapy, and Chemotherapy. JAMA. 1965;191(1):25. doi:10.1001/jama.1965.03080010031006
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