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Clinical Notes
January 4, 1965

Vacuolar Myopathy in Lupus Erythematosus

Author Affiliations

From the departments of internal medicine and pathology, University of Texas Medical Branch, Galveston.

JAMA. 1965;191(1):49-51. doi:10.1001/jama.1965.03080010055022

IN THE PAST, histological abnormalities of muscle in persons with systemic lupus erythematosus have been considered nonspecific.1-3 Recent reports, however, have suggested that there may be a specific vacuolar myopathy associated with lupus erythematosus.4 A patient having such an abnormality has been studied by us.

Report of a Case  This white female was first seen at the University of Texas Medical Branch in 1957 at 45 years of age. At that time she had a 14-month history of low-grade fever, intermittent dysphagia, dull substernal chest pains, and fleeting joint pains. Physical examination showed a chronically ill individual with temperature, 99.6 F (37.7 C); pulse, 120 beats per minute; respirations, 24 per minute; and blood pressure, 114/80 mm Hg. A few scattered medium moist rales were heard over both lung bases, and dullness to percussion was present over the right base. Moderate cardiomegaly and a presystolic gallop were noted.