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Brief Report
May 12, 1978

Reversibility of Severe Bleomycin-lnduced Pneumonitis

Author Affiliations

From the Division of Respiratory Sciences and the Department of Internal Medicine, University of Arizona, College of Medicine, and the Veterans Administration Hospital, Tucson.

JAMA. 1978;239(19):2012-2014. doi:10.1001/jama.1978.03280460080024

The use of bleomycin sulfate as an antineoplastic agent has been limited by its substantial pulmonary toxic effects. The exact incidence and prognosis of bleomycin-pneumonitis is unresolved. Although bleomycin pulmonary toxicity is thought to be dose-related, recent reports have emphasized severe reactions at low doses. Furthermore, severe pulmonary toxicity has been suggested to be progressive, irreversible, and ultimately, fatal. We report clinical, roentgenographic, and pathophysiologic recovery after severe, bleomycin-induced pneumonitis.

(JAMA 239:2012-2014, 1978)