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Landmark Article
February 24, 1984

Sodium Diphenyl Hydantoinate in the Treatment of Convulsive Disorders

Author Affiliations

From the Neurological Unit, Boston City Hospital, and the Department of Neurology, Harvard Medical School.

JAMA. 1984;251(8):1062-1067. doi:10.1001/jama.1984.03340320048027

Good results in the treatment of patients with convulsive seizures have been obtained by a variety of methods, such as medical treatment with bromides or barbituric acid compounds, the ketogenic diet, restriction of fluids, and the surgical excision of scars or irritable cortical foci. In spite of these various therapeutic means there are a great number of patients who are not relieved of their attacks or are helped only temporarily by treatment. The fact that treatment by anticonvulsant drugs is at present the most widely used and on the whole the most effective method of therapy suggested to us the possibility that a direct and systematic experimental search might reveal more potent and less sedative compounds. With this idea in mind we devised an experimental procedure1 which would produce convulsive seizures in animals at a constant threshold and which would allow for a qualitative and roughly quantitative determination of