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July 20, 1984

Reference Values for Plasma Lipids and Lipoproteins

JAMA. 1984;252(3):343-344. doi:10.1001/jama.1984.03350030017009

To the Editor.—  Reference values for plasma lipids and lipoproteins have recently been revised by the Lipids Research Clinics (LRC) Program1 and found to be higher than the traditional ones.2In the Centro Trasfusionale e di Immunologia dei Trapianti of the Ospedale Policlinico, Milan, regular blood donors undergo, at each donation, a physical examination and some biochemical analyses, including those of cholesterol and triglycerides. The results of laboratory tests are recorded, and a longitudinal individual biochemical profile thus becomes available for each donor.3We selected as a reference sample 14,942 subjects (9,849 males and 5,093 females), who, during a follow-up period of at least two years, had a negative clinical history and normal results at both physical examination and laboratory investigations (excluding lipids assay).The first recorded value of fasting cholesterol and triglycerides of each donor was used to calculate reference limits for sex and age classes.