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March 27, 1987

Serum Cholesterol and Death From Coronary Heart Disease

Author Affiliations

George Washington University Bethesda, Md

George Washington University Bethesda, Md

JAMA. 1987;257(12):1600. doi:10.1001/jama.1987.03390120061015

To the Editor.—  In a recent issue of JAMA, it was reported that among the primary participants in the MRFIT1— men aged 35 to 57 years—CHD death rates were greater at higher serum cholesterol levels, the lowest CHD death rates being at levels less than 182 mg/dL (4.71 mmol/L). This finding is consistent with a large body of other data, has been reported elsewhere for the MRFIT, and is presumably featured in this issue of JAMA for its "educational" value.It is curious, however, that the authors of this article mentioned nothing of the finding of their own study with respect to causes other than CHD, a finding implicit in an article from the MRFIT published almost simultaneously in another journal.2 From this article, the following six-year non-CHD death rates (per 1000) by quintile of serum cholesterol level for the MRFIT participants can be derived (Table).