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April 20, 1994

Randomized Clinical Trials in Single Patients-Reply

JAMA. 1994;271(15):1159-1160. doi:10.1001/jama.1994.03510390029019

In Reply.  —Dr Rodney asks questions about the costs of performing SPTs. As stated in our article, our estimates of time and costs are probably conservative. The following table lists the activity and time spent:Nearly half (43%) of the time spent in trial preparation was delegated to support persons. The interval office visits reported in our article were typically performed by a clinical pharmacist. We also did not account for indirect or overhead costs. Finally, a small grant allowed us to cover the start-up costs of forming an SPT service; these costs are not part of our calculations, but do need to be considered if a formal service is to be developed.1 This information demonstrates the cost components based on our experience. We believe the best way to establish the service would be to develop a standard fee schedule similar to those commonly used for diagnostic tests (eg, magnetic