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Lab Reports
August 7, 2013

Asthma Drug Improves Cognitive Function in Down Syndrome Model

Author Affiliations

Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2013;310(5):470. doi:10.1001/jama.2013.178400

Treating mice with Down syndrome with the asthma drug formoterol strengthened nerve connections in the hippocampus and improved cognitive function and the brain’s ability to integrate spatial and sensory information (Dang V et al. Biol Psychiatry. doi:10.1016/j.biopsych.2013.05.024 [published online July 2, 2013]). Postmortem analyses revealed more synapses and a more complex structure of nerve endings in the hippocampus in affected mice treated with the drug than in control animals, report investigators from the Stanford University School of Medicine in Palo Alto, Calif.