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Comment & Response
August 7, 2013

Therapy for Chemotherapy-Induced Peripheral Neuropathy

Author Affiliations
  • 1Cancer Research UK, University of Edinburgh, Edinburgh, Scotland
  • 2Western General Hospital, University of Edinburgh, Edinburgh, Scotland
JAMA. 2013;310(5):537-538. doi:10.1001/jama.2013.7902

To the Editor Dr Smith and colleagues1 concluded that “among patients with painful chemotherapy-induced peripheral neuropathy, the use of duloxetine compared with placebo for 5 weeks resulted in a greater reduction in pain.”

The overall strength of effect underpinning this conclusion, however, is relatively small, despite reaching statistical significance. The authors most clearly demonstrated this in Figure 2 in the article, which shows closely approximated or overlapping confidence intervals in both the initial and crossover treatment periods.