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Comment & Response
August 14, 2013

Efficacy of Sublingual Immunotherapy

Author Affiliations
  • 1Department of General Practice, Erasmus Medical Center, Rotterdam, the Netherlands
  • 2Department of Allergy, Erasmus Medical Center, Rotterdam, the Netherlands
JAMA. 2013;310(6):644. doi:10.1001/jama.2013.7643

To the Editor The review by Dr Lin and colleagues1 provided evidence for a moderate grade level of evidence to support the effectiveness of sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma. We would like to comment on the presentation of the included studies and the conclusion.

We performed 2 placebo-controlled studies in children with grass pollen allergy2 and house dust mite allergy3 that were included in the review as 2 of the 36 studies reporting on rhinitis symptom scores. The authors concluded that all 36 studies demonstrated greater improvement in rhinitis symptoms in the sublingual immunotherapy group compared with the placebo group. However, both our grass pollen study2 and our house dust mite study3 clearly demonstrated that there was no difference between the 2 treatment groups with respect to all outcome measures. Therefore, we were surprised to see that our studies were summarized as studies with improvement and would like to know how the authors made these determinations.