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Comment & Response
August 14, 2013

Efficacy of Sublingual Immunotherapy

Author Affiliations
  • 1Department of Medical and Surgical Specialty and Public Health, University of Perugia, Perugia, Italy
  • 2Allergy and Pulmonary Rehabilitation Unit, ICP Hospital, Milan, Italy
  • 3Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
JAMA. 2013;310(6):643-644. doi:10.1001/jama.2013.7646

To the Editor The primary objective of the systematic review by Dr Lin and colleagues1 was “to review the clinical efficacy and safety of sublingual immunotherapy delivered as an aqueous solution as can potentially be done in the United States.” The authors reported that there are physicians in the United States who use subcutaneous aqueous allergens off-label for sublingual desensitization. However, the doses administered by subcutaneous immunotherapy and sublingual immunotherapy are very different.