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Comment & Response
August 14, 2013

Efficacy of Sublingual Immunotherapy—Reply

Author Affiliations
  • 1Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland
  • 2Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland
JAMA. 2013;310(6):644-645. doi:10.1001/jama.2013.7652

In Reply We agree with Dr Frati and colleagues regarding the need for higher dosing with sublingual immunotherapy than subcutaneous immunotherapy. Although there are anecdotal reports of clinical use of sublingual immunotherapy in the United States, to our knowledge, there have been no published surveys of the dosing used by these physicians.

Frati and colleagues are correct that we did not report the ratio of sublingual to subcutaneous immunotherapy in our review, which is a useful comparator. However, this same information can be derived by using the micrograms per month of major allergen used in each study, which was included when available for each article in the supplementary materials.