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Comment & Response
August 21, 2013

Cryptococcosis in a Febrile Renal Transplant Recipient

Author Affiliations
  • 1Wayne State University, Detroit, Michigan
JAMA. 2013;310(7):748. doi:10.1001/jama.2013.124260

To the Editor In a JAMA Clinical Challenge, Drs Ding and Fang1 discussed a case study of cryptococcosis in a febrile renal transplant recipient. We wish to comment on the choice of itraconazole as therapy for this patient.

Cultures of the skin biopsy and sputum confirmed a diagnosis of disseminated cryptococcosis in this immunocompromised patient who was treated with intravenous itraconazole for the first 2 weeks. She died of meningoencephalitis of unclear etiology a few months later.