To the Editor: The ALLHAT authors1 do
not comment on the curious finding that patients who received chlorthalidone
were twice as likely as those assigned to amlodipine to die of unintentional
injury, suicide, or homicide. Although the absolute difference in the risk
(0.3 persons per 6-year per 100 persons) was small, it did reach statistical
significance. The difference in the rate between chlorthalidone and lisinopril
was in the same direction but did not reach statistical significance.
Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel
Blockers vs Angiotensin-Converting Enzyme Inhibitors. JAMA. 2003;289(16):2066. doi:10.1001/jama.289.16.2068-a
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