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April 23/30, 2003

Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors

JAMA. 2003;289(16):2066. doi:10.1001/jama.289.16.2068-b

To the Editor: The ALLHAT authors1 reported that during a 4-year period, glomerular filtration rate (GFR) was best preserved in the patients on amlodipine and declined most in those receiving chlorthalidone. The authors then dismissed this finding by suggesting that the African American Study of Kidney Disease and Hypertension (AASK) study2 group had pointed to a detrimental effect of amlodipine on renal function with a faster rate of decline of GFR.