In Reply: Dr Foulkes and colleagues raise an
interesting question regarding the woman in our study who was diagnosed with
DCIS at 37 years and who carries a mutation in both BRCA1 and BRCA2. We have recontacted this study
participant and found (after she gathered information from additional family
members) that both her maternal grandfather and grandmother were indeed of
French-Canadian descent as shown in the pedigree (Figure). The study by Oros et al1 reports
the 2 mutations identified in our study patient in several French-Canadian
hereditary breast-ovarian cancer families (but not in the same family or individual).
It will be of interest to define the relationship of the family identified
in our study to the families that this group has already identified.
BRCA. JAMA. 2005;294(5):553–554. doi:10.1001/jama.294.5.554-a