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August 10, 2005

Racial Differences in BRCA Testing

Author Affiliations
  • 1salford1@hfhs.org, Josephine Ford Cancer Center, Henry Ford Health System, Detroit, Mich
  • 2Medical Genetics, Kaiser Permanente Colorado, Denver
JAMA. 2005;294(6):677. doi:10.1001/jama.294.6.677-a

To the Editor: We are concerned about aspects of the study design in the article on racial differences in BRCA1/2 testing by Dr Armstrong and colleagues, and believe that the results should be interpreted with caution.1 In a case-control study, controls should be sampled from the population that gave rise to the cases.2,3 However, the description of this study leaves questions about whether appropriate sampling has occurred.