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February 15, 2012

Cancer Risk After Organ Transplantation

Author Affiliations

Author Affiliations: Prince of Wales Clinical School (Dr Vajdic) (claire.vajdic@unsw.edu.au), Kirby Institute (Dr Grulich), University of New South Wales, Sydney, Australia; and The Centenary Research Institute, Sydney, Australia (Dr McCaughan).

JAMA. 2012;307(7):663-664. doi:10.1001/jama.2012.140

To the Editor: Dr Engels and colleagues1 performed a large-scale, population-based linkage study of cancer risk after solid organ transplantation. The findings demonstrated an increased risk for a wide range of cancers after transplantation. However, the inclusion in the study of cancers prevalent at transplantation may have upwardly biased some risk estimates, rendering comparisons with other immunosuppressed populations problematic.